মঙ্গলবার, ৩০ এপ্রিল, ২০১৩

?Teen Mom? Farrah Abraham Sells Sex Tape Rights For Just Under $1 Million

“Teen Mom” Farrah Abraham Sells Sex Tape Rights For Just Under $1 Million

James Deen exposes Farrah AbrahamFarrah Abraham, who attempted to play off her sex tape with male porn star James Deen as a “personal tape”, has sold the rights to her XXX tape for almost $1 million. Farrah sold her movie, entitled “Farrah Superstar: Backdoor Teen Mom”, for close to a million dollars in a deal with Vivid Entertainment. The ...

“Teen Mom” Farrah Abraham Sells Sex Tape Rights For Just Under $1 Million Stupid Celebrities Gossip Stupid Celebrities Gossip News

Source: http://stupidcelebrities.net/2013/04/teen-mom-farrah-abraham-sells-sex-tape-rights-for-just-under-1-million/

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One hurt in self-inflicted shooting at Ohio high school

(Reuters) - One boy was injured in a self-inflicted shooting on Monday in a classroom at a high school in Cincinnati, Ohio, and has been taken to a local hospital, police said.

Green Township Police Chief Bart West said the school was briefly put on lockdown after the student pulled out a gun and shot himself in a classroom early Monday. The lockdown has since been lifted.

"All the other students in the building are OK," West said during a televised news conference.

He said the student who shot himself was being taken to University of Cincinnati Medical Center. He did not know the wounded student's condition.

It initially appeared that a second person might have been involved in the shooting at La Salle, an all-boys private college-preparation school in Cincinnati.

La Salle High School Director of Community Development Greg Tankersley said the building was secured quickly after the lockdown. Counselors are at the school to meet with students.

"We just ask that you keep this young man and his family in your prayers today," he said.

(Reporting by Colleen Jenkins; Editing by Gerald E. McCormick and Nick Zieminski)

Source: http://news.yahoo.com/one-hurt-another-apprehended-shooting-ohio-high-school-141125739.html

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Steven Spielberg "Obama" Biopic - Business Insider

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Ray J Releases Music Video for Kim Kardashian-Inspired Anthem

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Guardian newspaper?s Twitter feeds hacked

London: The Guardian newspaper says its Twitter accounts have come under a cyberattack, and it said the Syrian Electronic Army claimed responsibility for the same. The British paper reported on its website Monday that several of its Twitter feeds were broken into over the weekend.

It said it has since discovered that the attack apparently originated from Internet protocol addresses within Syria. The paper said the Syrian Electronic Army, which has claimed responsibility for attacks on other media targets including The Associated Press, accused The Guardian of spreading ?lies and slander about Syria?.

The Guardian said it first recognized it was being targeted when suspect emails were sent to staff members. Some of The Guardian?s Twitter accounts, including those focusing on books and film, were suspended Monday.

Source: http://www.livemint.com/Consumer/hb6KBkDVV22yIXt8cfUQvI/Guardian-newspapers-Twitter-feeds-hacked.html

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Big Sibling's Big Influence: Some Behaviors Run In The Family

Patricia East is a developmental psychologist who began her career working at an OB-GYN clinic in California. Thursday mornings at the clinic were reserved for pregnant teens, and when East arrived the waiting room would be packed with them, chair after chair of pregnant adolescents.

It was in this waiting room, East explains, that she discovered her life's work ? an accidental discovery that emerged from the small talk that staff at the clinic had with their young clients as they walked them back for checkups.

"The nurses and the doctors there would bring a teen back for her prenatal visit and they would say, 'Hey! Aren't you Maria's younger sister?' And the young woman would say, 'Yeah, I am!' And they would say to another patient, 'You know, haven't I seen you before?' And she would say, 'Yes, I was here for my older sister when she was pregnant.' "

Over and over East heard variations of this conversation, until it came to the point that when she saw a younger sibling sitting next to her sister in the waiting room an involuntary thought flashed across her mind.

"It's almost as if you're watching the younger sister get pregnant," she says.

And so East decided to do a study. She wanted to figure out if having an older sister who got pregnant as a teen really did affect the likelihood that the younger sibling would find herself in the same position. She identified a large number of sister pairs ? all pairs came from roughly the same socioeconomic and life circumstances. And by comparing them, she found that a pregnancy in an older sister did often seem to change the trajectory of the younger sibling.

"The younger sisters are five times more likely to get pregnant as other young women who have an older sister who hasn't been pregnant."

In the aftermath of the bombings in Boston many of us have been thinking a lot about siblings ? particularly how older siblings can shape the lives of younger siblings. But until pretty recently, the role siblings play in determining the trajectory of each other's lives hasn't been a particularly hot topic in psychological research. Psychologists, very understandably, have focused on the influences they see as more important ? such as parents and peers and genetics.

But in the past decade that's been changing a bit. Psychologists interested in how siblings affect one another are taking a new look at all kinds of behavior, particularly anti-social behavior.

Richard Rende, a professor of psychiatry at Brown University, is one of the people doing this work, and he says that some of the new findings really challenge the idea that parents are the most important influence on children.

Consider, for example, the research that looks at how much a parent who smokes influences his child to smoke, versus the degree to which an older sibling who smokes influences a younger sibling.

"Both can have an effect, but in a lot of studies they've found that the effect 'older sibling smoking' has is greater than the effect that 'parental smoking' has," Rende says.

It's the opposite of what many people assumed, he says. Older siblings are more influential.

Rende says you can see this influence of big brothers and sisters in all kinds of families ? rich, middle class and poor. But their power is really magnified in the particular subset of families he studies: families that are psychologically and economically unstable. In those families the power of the older sibling is much greater because parents aren't around as much, and the siblings tend to spend a lot of time together.

As part of his research, Rende gives sibling pairs electronic devices like cellphones that, every half hour, prompt both siblings to report what they're doing. Through such reports you can actually see each one ghosting the other's behavior, he says.

"When one sibling is smoking ? in real time [we see] they're having a cigarette, and the other sibling is very likely to report smoking at the same time."

In fact, when one sibling is a smoker, the other is 25 percent more likely to smoke. With drinking the risk is even higher; a person is 36 percent more likely to drink if a sibling does.

Rende, by the way, believes that the reverse is also true. Good behavior in older siblings can be as contagious as bad. It just seems that ? particularly when families are struggling ? the fate of the kids is more tethered to their siblings than we originally thought. For good and, apparently, for bad.

Source: http://www.npr.org/blogs/health/2013/04/29/179266284/Big-Siblings-Big-Influence-Some-Behaviors-Run-In-The-Family?ft=1&f=1007

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সোমবার, ২৯ এপ্রিল, ২০১৩

Dinosaur predecessors gain ground in wake of world's biggest biodiversity crisis

Apr. 29, 2013 ? Many scientists have thought that dinosaur predecessors missed the race to fill habitats emptied when nine out of 10 species disappeared during Earth's largest mass extinction, approximately 252 million years ago. The thinking was based on fossil records from sites in South Africa and southwest Russia.

It turns out that scientists may have been looking for the starting line in the wrong places.

Newly discovered fossils from 10 million years after the mass extinction reveal a lineage of animals thought to have led to dinosaurs taking hold in Tanzania and Zambia in the mid-Triassic period, many millions of years before dinosaur relatives were seen in the fossil record elsewhere on Earth.

"The fossil record from the Karoo of South Africa remains a good representation of four-legged land animals across southern Pangea before the extinction event. But after the event animals weren't as uniformly and widely distributed as before. We had to go looking in some fairly unorthodox places," said Christian Sidor, University of Washington professor of biology. He's lead author of a paper appearing the week of April 29 in the early edition of the Proceedings of the National Academy of Sciences.

The new insights come from seven fossil-hunting expeditions since 2003 in Tanzania, Zambia and Antarctica, funded by the National Geographic Society and National Science Foundation, along with work combing through existing fossil collections. The researchers created two "snapshots" of four legged-animals about 5 million years before and again about 10 million years after the extinction event at the end of the Permian period.

Prior to the extinction event, for example, the pig-sized Dicynodon -- said to resemble a fat lizard with a short tail and turtle's head -- was a dominant plant-eating species across southern Pangea. Pangea is the name given to the landmass when all the world's continents were joined together. Southern Pangea was made up of what is today Africa, South America, Antarctica, Australia and India. After the mass extinction at the end of the Permian, Dicynodon disappeared and other related species were so greatly decreased that newly emerging herbivores could suddenly compete with them.

"Groups that did well before the extinction didn't necessarily do well afterward," Sidor said. "What we call evolutionary incumbency was fundamentally reset."

The snapshot 10 million years after the extinction event reveals, among other things, that archosaurs were in Tanzanian and Zambian basins, but not distributed across all of southern Pangea as had been the pattern for four-legged animals prior to the extinction. Archosaurs are the group of reptiles that includes crocodiles, dinosaurs, birds and a variety of extinct forms. They are of interest because it is thought they led to animals like Asilisaurus, a dinosaur-like animal, and Nyasasaurus parringtoni, a dog-sized creature with a five-foot tail that scientists in December 2012 announced could be the earliest dinosaur, or else the closest relative found so far.

"Early archosaurs being found mainly in Tanzania is an example of how fragmented communities became after the extinction event," Sidor said. And the co-authors write: "These findings suggest that . . . archosaur diversification was more intimately related to recovery from the end-Permian mass extinction than previously suspected."

A new framework for analyzing biogeographic patterns from species distributions, developed by co-author Daril Vilhena, a UW biology graduate student, provided a way to discern the complex recovery, Sidor said.

It revealed that before the extinction event 35 percent of four-legged species were found in two or more of the five areas studied, with some species having ranges that stretched 1,600 miles (2,600 kilometers), encompassing the Tanzanian and South African basins. Ten million years after the extinction event, the authors say there was clear geographic clustering and just 7 percent of species were found in two or more regions.

The techniques -- new ways to statistically consider how connected or isolated species are from each other -- could be useful for other paleontologists and modern day biogeographers, Sidor said.

In the early 2000s Sidor and some of his co-authors started putting together expeditions to collect fossils from sites in Tanzania that hadn't been visited since the 1960s and in Zambia where there'd been little work since the '80s. Two expeditions to Antarctica provided additional materials, as did long-term efforts to examine museum-held fossils that had not been fully documented or named.

Other co-authors from the UW are graduate students Adam Huttenlocker and Brandon Peecook, post-doctoral researcher Sterling Nesbitt and research associate Linda Tsuji; Kenneth Angielczyk of the Field Museum of Natural History in Chicago; Roger Smith, of the Iziko South African Museum in Cape Town; and S?bastien Steyer from the National Museum of Natural History in Paris.

Funding was also received from the Evolving Earth Foundation, the Grainger Foundation, the Field Museum/IDP Inc. African Partners Program and the National Research Council of South Africa.

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The above story is reprinted from materials provided by University of Washington. The original article was written by Sandra Hines.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Christian A. Sidor, Daril A. Vilhena, Kenneth D. Angielczyk, Adam K. Huttenlocker, Sterling J. Nesbitt, Brandon R. Peecook, J. S?bastien Steyer, Roger M. H. Smith, and Linda A. Tsuji. Provincialization of terrestrial faunas following the end-Permian mass extinction. PNAS, April 29, 2013 DOI: 10.1073/pnas.1302323110

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/t4B8Gs8a5mE/130429154059.htm

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Iraq suspends Al-Jazeera and 9 Iraqi TV channels

BAGHDAD (AP) ? Iraqi authorities suspended the operating licenses of pan-Arab broadcaster Al-Jazeera and nine Iraqi TV channels on Sunday after accusing them of escalating sectarian tension. The move signaled the Shiite-led government's mounting worries over deteriorating security amid Sunni unrest and clashes that have left more than 180 people dead in less than a week.

The suspensions, which took effect immediately, appeared to target mainly Sunni channels known for criticizing Prime Minister Nouri al-Malik's government. Apart from Al-Jazeera, the decision affected eight Sunni and one Shiite channels.

The government's action comes as Baghdad tries to quell rising unrest in the country that erupted last week after Iraqi security forces launched a deadly crackdown on a Sunni protest site in the central city of Hawija, killing 23 people, including three soldiers.

Since then, more than 180 people have been killed in gunbattles with security forces and other attacks. The recent wave of violence follows more than four months of largely peaceful protests by Iraq's Sunni Muslim minority against Prime Minister Nouri al-Maliki's government.

Iraqi viewers will still be able to watch the channels, but the suspensions issued by Iraq's Communications and Media Commission state that if the 10 stations try to work on Iraqi territory they will face legal action from security forces. The decree essentially prevents news crews from the stations from reporting on activities in Iraq.

Sunni lawmaker Dahfir al-Ani described the move as part of the government's attempts "to cover up the bloodshed that took place in Hawija and what is going on in other places in the country."

Al-Jazeera, based in the small, energy-rich Gulf nation of Qatar, said it was "astonished" by the move.

"We cover all sides of the stories in Iraq, and have done for many years. The fact that so many channels have been hit all at once, though, suggests this is an indiscriminate decision," it said in an emailed statement. "We urge the authorities to uphold freedom for the media to report the important stories taking place in Iraq."

The channel has aggressively covered the "Arab Spring" uprisings across the region, and has broadcast extensively on the civil war in neighboring Syria. Qatar itself is a harsh critic of the Syrian regime. The nation is a leading backer of the rebels and is accused by many supporters of the Iraqi government of backing protests in Iraq too.

Newspapers and media outlets sprang up across Baghdad after the fall of the Saddam Hussein regime in 2003, yet Iraq remains one of the deadliest countries for reporters with more than 150 killed since 1992, according to the Committee to Protect Journalists.

Iraq and other governments across the Middle East have temporarily shut down Al-Jazeera's offices in the past because they were disgruntled by its coverage.

The other nine channels whose licenses were suspended by the Iraqi media commission are al-Sharqiya and al-Sharqiya News, which frequently criticize the government, and seven smaller local channels ? Salahuddin, Fallujah, Taghyeer, Baghdad, Babiliya, Anwar 2 and al-Gharbiya.

The Baghdad-based Baghdad TV said the decision was politically motivated.

"The Iraqi authorities do not tolerate any opposite opinions and are trying to silence any voices that do not go along with the official line," said Omar Subhi, who directs the news section.

He added that the TV station was concerned about the safety of its staff, fearing that security forces might chase them.

In a statement posted on its website, the government media commission blamed the banned stations for the escalation of sectarian tension that is fueling the violence that followed the deadly clashes in Hawija.

Iraq's media commission accused the stations of misleading and exaggerated reports, airing "clear calls for disorder" and "launching retaliatory criminal attacks against security forces." It also blamed the stations for promoting "banned terrorist organizations who committed crimes against Iraqi people."

Osama Abdul-Rahman, a Sunni government employee from northern Baghdad, said the government is adopting a double-standard policy regarding media outlets by turning a blind eye on several Shiite channels that he claims also incite violence.

"The channels close to main Shiite parties and even the state-run television also broadcast sectarian programs promoting violence all the time, yet, nobody stops them," he added.

Erin Evers, a Mideast researcher for Human Rights Watch, called the government's claim that it moved against the channels because they were inciting sectarianism suspicious given its "consistent history of cracking down on media ? particularly opposition media ? during politically sensitive times."

"The cancellation of these stations' licenses is further evidence that the government seeks to prevent the coverage of news they do not like," she said.

She accused the Iraqi media commission of confusing coverage of a speech with sectarian overtones with the active promotion of sectarian violence. "These are two completely different things and the first is protected under international and Iraqi law," she said.

The decision to suspend the stations came as al-Maliki made a rare appearance at an official funeral for five soldiers killed on Saturday by gunmen in Sunni-dominated Anbar province. Local police in the province said the soldiers were killed in a gunbattle after their vehicle was stopped near a Sunni protest camp.

Authorities had given protest organizers a 24-deadline to hand over the gunmen behind the killing or face a "firm response." No one has been handed over and the deadline passed.

Wrapped in Iraqi flags, the five caskets were loaded on military trucks next to flower bouquets, as soldiers held pictures of the deceased and grieved families gathered outside the Defense Ministry building in Baghdad's heavily fortified Green Zone.

In Saturday violence, gunmen using guns fitted with silencers shot dead two Sunni local tribal leaders in two separate drive-by shootings south of Baghdad.

___

Associated Press writers Adam Schreck and Sinan Salaheddin in Baghdad contributed.

Source: http://news.yahoo.com/iraq-suspends-al-jazeera-9-iraqi-tv-channels-192532800.html

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The integrated prom was a whopping success (Americablog)

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রবিবার, ২৮ এপ্রিল, ২০১৩

21 Jump Street 2 Release Date: Revealed!

Source: http://www.thehollywoodgossip.com/2013/04/21-jump-street-2-release-date-revealed/

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Russia caught bomb suspect on wiretap

WASHINGTON (AP) ? Russian authorities secretly recorded a telephone conversation in 2011 in which one of the Boston bombing suspects vaguely discussed jihad with his mother, officials said Saturday, days after the U.S. government finally received details about the call.

In another conversation, the mother of now-dead bombing suspect Tamerlan Tsarnaev was recorded talking to someone in southern Russia who is under FBI investigation in an unrelated case, officials said.

The conversations are significant because, had they been revealed earlier, they might have been enough evidence for the FBI to initiate a more thorough investigation of the Tsarnaev family.

As it was, Russian authorities told the FBI only that they had concerns that Tamerlan and his mother were religious extremists. With no additional information, the FBI conducted a limited inquiry and closed the case in June 2011.

Two years later, authorities say Tamerlan and his brother, Dzhohkar, detonated two homemade bombs near the finish line of the Boston Marathon, killing three and injuring more than 260. Tamerlan was killed in a police shootout and Dzhohkar is under arrest.

In the past week, Russian authorities turned over to the United States information it had on Tamerlan and his mother, Zubeidat Tsarnaeva. The Tsarnaevs are ethnic Chechens who emigrated from southern Russia to the Boston area over the past 11 years.

Even had the FBI received the information from the Russian wiretaps earlier, it's not clear that the government could have prevented the attack.

In early 2011, the Russian FSB internal security service intercepted a conversation between Tamerlan and his mother vaguely discussing jihad, according to U.S. officials who spoke on condition of anonymity because they were not authorized to discuss the investigation with reporters.

The two discussed the possibility of Tamerlan going to Palestine, but he told his mother he didn't speak the language there, according to the officials, who reviewed the information Russia shared with the U.S.

In a second call, Zubeidat Tsarnaeva spoke with a man in the Caucasus region of Russia who was under FBI investigation. Jacqueline Maguire, a spokeswoman for the FBI's Washington Field Office, where that investigation was based, declined to comment.

There was no information in the conversation that suggested a plot inside the United States, officials said.

It was not immediately clear why Russian authorities didn't share more information at the time. It is not unusual for countries, including the U.S., to be cagey with foreign authorities about what intelligence is being collected.

The FSB said Sunday that it would not comment.

Jim Treacy, the FBI's legal attache in Moscow between 2007 and 2009, said the Russians long asked for U.S. assistance regarding Chechen activity in the United States that might be related to terrorism.

"On any given day, you can get some very good cooperation," Treacy said. "The next you might find yourself totally shut out."

Zubeidat Tsarnaeva has denied that she or her sons were involved in terrorism. She has said she believed her sons have been framed by U.S. authorities.

But Ruslan Tsarni, an uncle of the Tsarnaev brothers and Zubeidat's former brother-in-law, said Saturday he believes the mother had a "big-time influence" as her older son increasingly embraced his Muslim faith and decided to quit boxing and school.

After receiving the narrow tip from Russia in March 2011, the FBI opened a preliminary investigation into Tamerlan and his mother. But the scope was extremely limited under the FBI's internal procedures.

After a few months, they found no evidence Tamerlan or his mother were involved in terrorism.

The FBI asked Russia for more information. After hearing nothing, it closed the case in June 2011.

In the fall of 2011, the FSB contacted the CIA with the same information. Again the FBI asked Russia for more details and never heard back.

At that time, however, the CIA asked that Tamerlan's and his mother's name be entered into a massive U.S. terrorism database.

The CIA declined to comment Saturday.

Authorities have said they've seen no connection between the brothers and a foreign terrorist group. Dzhohkar told FBI interrogators that he and his brother were angry over wars in Afghanistan and Iraq and the deaths of Muslim civilians there.

Family members have said Tamerlan was religiously apathetic until 2008 or 2009, when he met a conservative Muslim convert known only to the family as Misha. Misha, they said, steered Tamerlan toward a stricter version of Islam.

Two U.S. officials say investigators believe they have identified Misha. While it was not clear whether the FBI had spoken to him, the officials said they have not found a connection between Misha and the Boston attack or terrorism in general.

___

Associated Press writer Adam Goldman in Washington and Michael Kunzelman in Boston contributed to this report.

Source: http://news.yahoo.com/russia-caught-bomb-suspect-wiretap-105240857.html

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EVE Online dev reveals Oculus Rift-based space dogfighting 'experience'

EVE Online developers reveal 'EveVR' running in Unity

It's not clear if Icelandic game studio CCP is extending its crazy MMO, EVE Online, into the world of virtual reality, but the company is working on some form of EVE-based VR application using the Oculus Rift. CCP teased the concept during the keynote event at its Fanfest event this afternoon, showing off what looked like a modern Wing Commander-style space shooter set in the world of EVE (similar to the first-person shooter extension on PlayStation 3, Dust 514), built using the Unity game engine. EVE fansite The Mittani notes from a hands-on demonstration at Fanfest that the game is currently 3v3 dogfighting employing the VR headset and an unnamed "console-style game controller." Sadly, it sounds like the project is little more than an internal curiosity at this point, but color us unsurprised if this pops up in a more polished form down the line. We'll add a video of CCP's presentation to this post as soon as it goes live -- we were marveled by the gorgeous visuals and gameplay promise of a space shooter which employs VR.

Several games are currently in development for the Oculus Rift, and Valve's Team Fortress 2 already supports the device. However, the headset that's currently available is a development kit, and not meant as representative of the final retail product.

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Source: http://www.engadget.com/2013/04/26/eve-online-oculus-rift/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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NKorea charges US man of plot to overthrow regime

In this March 20, 2013 photo, a North Korean flag hangs inside the interior of Pyongyang?s Supreme Court. North Korea says it will soon deliver a verdict in the case of detained American Kenneth Bae it accuses of trying to overthrow the government, further complicating already fraught relations between Pyongyang and Washington. The announcement about Bae comes in the middle of a lull after weeks of war threats and other provocative acts by North Korea against the U.S. and South Korea. Bae, identified in North Korean state media by his Korean name, Pae Jun Ho, is a tour operator of Korean descent who was arrested after arriving with a tour on Nov. 3 in Rason, a special economic zone bordering China and Russia. (AP Photo)

In this March 20, 2013 photo, a North Korean flag hangs inside the interior of Pyongyang?s Supreme Court. North Korea says it will soon deliver a verdict in the case of detained American Kenneth Bae it accuses of trying to overthrow the government, further complicating already fraught relations between Pyongyang and Washington. The announcement about Bae comes in the middle of a lull after weeks of war threats and other provocative acts by North Korea against the U.S. and South Korea. Bae, identified in North Korean state media by his Korean name, Pae Jun Ho, is a tour operator of Korean descent who was arrested after arriving with a tour on Nov. 3 in Rason, a special economic zone bordering China and Russia. (AP Photo)

In this March 20, 2013 photo, a North Korean flag hangs inside the interior of Pyongyang?s Supreme Court. North Korea says it will soon deliver a verdict in the case of detained American Kenneth Bae it accuses of trying to overthrow the government, further complicating already fraught relations between Pyongyang and Washington. The announcement about Bae comes in the middle of a lull after weeks of war threats and other provocative acts by North Korea against the U.S. and South Korea. Bae, identified in North Korean state media by his Korean name, Pae Jun Ho, is a tour operator of Korean descent who was arrested after arriving with a tour on Nov. 3 in Rason, a special economic zone bordering China and Russia. (AP Photo)

(AP) ? North Korea announced Saturday that an American detained for nearly six months is being tried in the Supreme Court on charges of plotting to overthrow the government, a crime that could draw the death penalty if he is convicted.

The case involving Kenneth Bae, who has been in North Korean custody since early November, further complicates already fraught relations between Pyongyang and Washington following weeks of heightened rhetoric and tensions.

The trial mirrors a similar situation in 2009, when the U.S. and North Korea were locked in a standoff over Pyongyang's decision to launch a long-range rocket and conduct an underground nuclear test. At the time, North Korea had custody of two American journalists, whose eventual release after being sentenced to 12 years of hard labor paved the way for diplomacy following months of tensions.

Bae was arrested in early November in Rason, a special economic zone in North Korea's far northeastern region bordering China and Russia, according to official state media. In North Korean dispatches, Bae, a Korean American, is called Pae Jun Ho, the North Korean spelling of his Korean name.

The exact nature of his alleged crimes has not been revealed, but North Korea accuses Bae, described as a tour operator, of seeking to overthrow North Korea's leadership.

"In the process of investigation he admitted that he committed crimes aimed to topple the DPRK with hostility toward it," the state-run Korean Central News Agency said Saturday. "His crimes were proved by evidence. He will soon be taken to the Supreme Court of the DPRK to face judgment."

DPRK is the acronym for North Korea's official name, the Democratic People's Republic of Korea. No timing for the verdict issued at the austere Supreme Court in Pyongyang was given.

Friends and colleagues described Bae as a devout Christian from Washington state but based in the Chinese border city of Dalian who traveled frequently to North Korea to feed the country's orphans.

At least three other Americans detained in recent years also have been devout Christians. While North Korea's constitution guarantees freedom of religion, in practice only sanctioned services are tolerated by the regime.

Under North Korea's criminal code, crimes against the state can draw life imprisonment or the death sentence.

In 2009, American journalists Laura Ling and Euna Lee were sentenced to hard labor for trespassing and unspecified hostile acts after being arrested near the border with China and held for four months.

They were freed later that year to former President Bill Clinton, who flew to Pyongyang to negotiate their release in a visit that then-leader Kim Jong Il treated as a diplomatic coup.

Including Ling and Lee, Bae is at least the sixth American detained in North Korea since 2009. The others eventually were deported or released.

"For North Korea, Bae is a bargaining chip in dealing with the U.S.," said Koh Yu-hwan, a professor of North Korean Studies at Dongguk University in Seoul, South Korea. "The North will use him in a way that helps bring the U.S. to talks when the mood slowly turns toward dialogue."

As in 2009, Pyongyang is locked in a standoff with the Obama administration over North Korea's drive to build nuclear weapons.

Washington has led the campaign to punish Pyongyang for launching a long-range rocket in December and carrying out a nuclear test, its third, in February.

North Korea claims the need to build atomic weapons to defend itself against the United States, which has 28,500 troops in South Korea and over the past two months has been holding joint military drills with South Korea that have included nuclear-capable stealth bombers and fighter jets.

Diplomats from China, South Korea, the U.S., Japan and Russia have been conferring in recent weeks to try to bring down the rhetoric and find a way to rein in Pyongyang before a miscalculation in the region sparks real warfare.

South Korean defense officials said earlier in the month that North Korea had moved a medium-range missile designed to strike U.S. territory to its east coast.

The Korean Peninsula remains in a technical state of war because the three-year Korean conflict ended in a truce, not a peace treaty, in 1953. Because Washington and Pyongyang do not have diplomatic relations, the Swedish Embassy in North Korea represents the United States in legal proceedings.

___

Associated Press writers Jean H. Lee in Pyongyang, and Sam Kim and Hyung-jin Kim in Seoul, South Korea, contributed to this report. Follow Lee, AP's Korea bureau chief, at www.twitter.com/newsjean and Sam Kim at www.twitter.com/SamKim_AP.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-04-27-NKorea-American%20Detained/id-e4e360d7a6f14d23ac431a5e1efbba3b

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Team of rivals: Italy, finally, forms new government (+video)

Center-left leader Enrico Letta will be Italy's new prime minister, after his party formed a coalition government with former Premier Silvio Berlusconi's conservatives.

By Frances D'Emilio,?Associated Press / April 27, 2013

Italian Premier-designate Enrico Letta speaks at the Quirinale Presidential Palace in Rome, Saturday, April 27, 2013. Italy has finally has a new government, a coalition of Berlusconi's forces and center-left rivals who forged an unusual alliance.

(AP Photo/Domenico Stinellis)

Enlarge

Center-left leader Enrico Letta forged a new Italian government Saturday in a coalition with former Premier Silvio Berlusconi's conservatives, an unusual alliance of bitter rivals that broke a two-month political stalemate from inconclusive elections in the recession-mired country.

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The daunting achievement was pulled off by Letta, who will be sworn in as premier along with the new Cabinet on Sunday at the presidential Quirinal Palace.

Letta, 46, is a moderate with a reputation as a political bridge-builder. He is also the nephew Berlusconi's longtime adviser, Gianni Letta, a relationship seen as smoothing over often nasty interaction between the two main coalition partners.

Serving as deputy premier and interior minister will be Berlusconi's top political aide, Angelino Alfano. He is a former justice minister who was the architect of legislation that critics say was tailor-made to help media mogul Berlusconi in his many judicial woes.

The creation of the coalition capped the latest political comeback for Berlusconi, a former three-time premier who was forced to resign in 2011 as Italy slid deeper in to the eurozone's sovereign debt crisis.

On Monday, Letta is expected to lay out his strategy to Parliament, ahead of required confidence votes from the Chamber of Deputies and the Senate.

"We negotiated for the formation of the government without throwing up any stop signs," Berlusconi to told one of his TV networks. "That's how we contributed to forming a government in short time" after Letta was tapped Wednesday.

Berlusconi, a fervent anti-Communist, views Italy's left as a personal nemesis, and Letta's Democratic Party has some of its roots in what was the West's largest Communist Party.

Letta expressed "sober satisfaction over the team we put together and its willingness" to form a coalition.

Only a few weeks earlier, the head of the Democrats, Pier Luigi Bersani, resigned from the party post in humiliation and he refused Berlusconi's offer for a "grand coalition" and futilely tried to form a government without the center-right. Letta was a Bersani loyalist.

Bersani hailed the coalition formula as a "necessary compromise" that gives the country "freshness and solidarity."

The No. 3 bloc in Parliament, the anti-establishment 5 Star Movement, is led by comic Beppe Grillo, who ruled out any alliance with the largely sullied political class that has ruled Italy for decades.

President Giorgio Napolitano, who tasked Letta with creating a government out of bitter rivals, called upon the coalition partners to work "in a spirit of absolute, indispensable cohesion" as they work for sorely needed political and economic reforms.

The 87-year-old head of state sounded almost breathless as he expressed confidence the rivals could work together "without conflict or prejudices to find the right solutions" to the country's pressing economic and political problems.

Napolitano didn't name the challenges, but they include fighting unemployment, especially for young people, and corruption sullying much of the political class.

Napolitano said: "It was and is the only possible government," and one "whose formation couldn't be delayed further, in the interest of our country and of Europe."

He reluctantly agreed to be re-elected by Parliament earlier this month for another seven-year term because of the political instability.

Italy's economy is No. 3 among eurozone members, and financial markets have been anxiously watching to see if an effective government could be formed to carry on with outgoing Premier Mario Monti's efforts to keep the country from sliding into the eurozone's sovereign debt crisis.

Some Italian political observers have predicted such a hybrid government might last only a few months of Parliament's five-year term, before collapsing in squabbling.

But the fear of elections, especially after the lightning-quick rise of comic Grillo's grassroots movement, could prove to be strong glue.

Giovanni Orsina, deputy director of LUISS university's school of government in Rome, ventured that Letta's new coalition could "last more than we expect, 18 to 24 months, more or less."

The history professor cited "lack of alternatives, and because I believe Parliament's members are not particularly eager to get back to the polling booth and face new elections."

Voters, fed up with new and higher taxes, including a despised property tax revived by Monti, rejected his severe austerity policies.

The small centrist party created in time for the election by Monti, an economist and former European Union commissioner, will participate in the coalition, although Monti won't be in the Cabinet, which is heavy on two novelties ? a large presence of female ministers and Italy's first black minister.

A native of Congo, Cecile Kyenge is a doctor who will serve as minister of integration. Proposals to make it easier for Italy' growing immigrant population to become citizens have gone nowhere in Parliament amid fierce opposition from the anti-immigrant Northern League party. The party, a Berlusconi ally, isn't in the new government.

Prominent among the women in the Cabinet is Emma Bonino, a former EU commissioner and Radical Party leader who will serve as foreign minister. Olympic gold medal kayaker Josefa Idem was tapped as minister of equal opportunity and sports.

Letta comes from a moderate wing of the left-rooted Democratic Party that is close to the Vatican. Since Parliament always includes an array of lawmakers enjoying good ties to the politically influential Catholic church in Italy, this was one more qualification on Letta's bridge-building resume.

The father of three sons, he lives in Rome's working-class Testaccio neighborhood. When he was tapped by Napolitano on Wednesday, he drove his own car to the Quirinal Palace, in what was seen as a photo opportunity gesture to Italian taxpayers who widely despise the huge fleet of luxury cars that shuttles around ministers and lawmakers.

In 1998, when he was 32, Letta became the youngest minister in Italy's history when he served as minister for European policy for then-Premier Massimo D'Alema, an ex-Communist leader. Letta seemed a natural for that post. He spent his childhood in Strasbourg, home to the European Parliament, and studied international law before jumping into politics.

Copyright 2013 The Associated Press.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/WJ77Gys4ack/Team-of-rivals-Italy-finally-forms-new-government-video

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Bombing Suspect's Mom on Terrorism List (ABC News)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/301869368?client_source=feed&format=rss

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Murder suspect missing since 1999 surrenders

LAWTON, Okla. (AP) ? Authorities say a murder suspect who's been on the run since a brazen escape from an Oklahoma jail with eight other inmates in 1999 has turned himself in.

David Lee Kemp was the only inmate to elude capture after escaping the Comanche County jail on March 11, 1999. He was awaiting trial on two first-degree murder counts in the killings of his ex-wife and her boyfriend. Authorities say the inmates escaped after overpowering a guard using a large barbecue fork.

Comanche County Sheriff Kenny Stradley says Kemp, 43, was arrested early Friday. Comanche County is 80 miles southwest of Oklahoma City.

The FBI says Kemp was spotted in Las Vegas and may have visited Phoenix and Louisiana. FBI spokesman Rick Rains says Kemp turned himself in.

Source: http://news.yahoo.com/inmate-missing-since-1999-surrenders-oklahoma-162641201.html

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শনিবার, ২৭ এপ্রিল, ২০১৩

White House hedges on 'red line'

President Barack Obama during his meeting Friday with King Abdullah II of Jordan. (Pablo Martinez Monsivais/AP???A whole bunch,? meet ?systematic.? President Barack Obama's cautious stance on the conflict in Syria shone clearly Friday as he warned President Bashar Assad that ?the systematic use? of chemical weapons against Syrian rebels would trigger a forceful American response.

Back in August, Obama bluntly warned Assad?s regime that while he had not ?at this point? ordered an American military response to Syria's civil war, ?a red line for us is we start seeing a whole bunch of chemical weapons moving around or being utilized."

When it comes to chemical weapons, what is "a whole bunch"? What does "systematic" mean? The White House has carefully refused to define either term precisely, keeping the president's options open. Republicans have called for a far more forceful U.S. role in Syria, notably by arming the rebels and establishing "safe zones" to protect the opposition or Syrians fleeing the fighting.

In 2008, Obama used his opposition to the Iraq war?and Hillary Clinton?s initial support for it?as a potent weapon to capture the Democratic presidential nomination. The flawed case for toppling Saddam Hussein looms large now as the president wrestles with the U.S. response to signs that Assad?s iron-fisted regime used chemical weapons in Syria?s two-year civil war. The conflict has claimed the lives of an estimated 70,000 people.

?I think all of us, not just in the United States but around the world, recognize how we cannot stand by and permit the systematic use of weapons like chemical weapons on civilian populations,? Obama said as he met Friday in the Oval Office with King Abdullah II of Jordan.

The president?s comments came a day after Defense Secretary Chuck Hagel and the White House revealed that U.S. intelligence believed Assad had used chemical weapons, specifically the deadly nerve agent sarin, against opposition forces in the country's ongoing civil war.

On Thursday, the White House disclosed that "our intelligence community does assess with varying degrees of confidence" that Assad's regime had used sarin. But top officials?from Hagel on down?warned that those findings did not mean that Assad had now crossed Obama's "red line" or that American military action might be imminent. Instead, they said Washington will now work with its allies, Syria's opposition and the United Nations to build what one top Obama aide called an ?airtight? case.

"These are preliminary assessments; they?re based on our intelligence gathering. We have varying degrees of confidence about the actual use, but there are a range of questions around how, when, where these weapons may have been used," Obama said Friday, vowing "to make sure that we are investigating this as effectively and as quickly as we can."

"But I meant what I?d said, and I will repeat," he said. "Horrific as it is when mortars are being fired on civilians and people are being indiscriminately killed, to use potential weapons of mass destruction on civilian populations crosses another line with respect to international norms and international law. And that is going to be a game changer."

"We have to act prudently. We have to make these assessments deliberately. But I think all of us, not just in the United States but around the world, recognize how we cannot stand by and permit the systematic use of weapons like chemical weapons on civilian populations," he said.

Just how big a factor is the March 2003 invasion of Iraq? A senior Obama aide, briefing reporters Thursday on a conference call arranged by the White House, made repeated references to it as a reason to tread cautiously.

?I?d say that given our own history with intelligence assessments, including intelligence assessments related to weapons of mass destruction, it?s very important that we are able to establish this with certainty and that we are able to present information that is airtight in a public and credible fashion," he said. "That is, I think, the threshold that is demanded."

White House press secretary Jay Carney sharply rejected any notion that Obama might show more "leniency" on weapons of mass destruction because of the Iraq War. "Absolutely not," he told reporters at his Friday briefing.

"The fact is that we do have some evidence and we need to build on that," Carney said. "The precedent you cite I think is a significant one, and it simply stands to reason that the assessments that we make, the intelligence community makes, are extraordinarily valuable, and they do excellent work, but they are building blocks towards a broader objective here, which is the accumulation of concrete evidence?evidence that can be corroborated, evidence that can be presented and reviewed and then acted on if the conclusion is that a red line has been crossed."

Source: http://news.yahoo.com/blogs/ticket/iraq-looms-large-wary-obama-warns-syria-over-201513845.html

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Protein shaped like a spider

Protein shaped like a spider [ Back to EurekAlert! ] Public release date: 26-Apr-2013
[ | E-mail | Share Share ]

Contact: Dr. Jan Grabowski
jan.grabowski@helmholtz-hzi.de
49-531-618-11407
Helmholtz Centre for Infection Research

Joint press release of the Helmholtz Centre for Infection Research and the Technische Universitat Darmstadt -- The immune protein C4BP is potentially suitable as a transporter for drugs

This press release is available in German.

The protein C4BP is similar to a spider in its spatial form with eight "arms". The structure of the "spider body" has recently been described in detail by researchers from the Helmholtz Centre for Infection Research (HZI) in Braunschweig and the Technische Universitt Darmstadt. This leads the scientists to unconventional ideas the protein is possibly suitable as a scaffold for the transport of active pharmaceutical substances, particularly biomolecules. The researchers are publishing their results in the current edition of the international journal Journal of Molecular Biology.

The so-called complement system is a part of the innate immune defence within the human body: more than sixty different proteins form one of the first countermeasures against invading pathogens. One of them is the C4b binding protein known as C4BP. It is involved in the immune defence against bacteria in the blood. How precisely such protein substance carries out its function or how it interacts with other molecules this can only be predicted by scientists once they have identified the spatial structure of the molecule. Structural biologists therefore examine the substance in its purest form with x-ray machines and are able to reconstruct the spatial design in a computer. Regarding the case of the recently-described C4BP, they found out that it has eight "arms" and thus resembles a spider to a certain degree. Seven of the "arms" are identical as "alpha chains", while the eighth, a "beta chain" is different from the others. The spider body that holds these side chains together is called the oligomerisation domain. Its structure was of special interest to researchers, since it determines the spatial alignment of the "arms".

The newly-described structure allows two possible variants. "However, there is one of these two possibilities that is more feasible because it is much more stable", says Thomas Hofmeyer, PhD student at the Institute for Organic Chemistry and Biochemistry of TU Darmstadt and first author for the publication. And the C4BP is quite stable, as explained by the other first author Dr. Stefan Schmelz from the Department of Molecular Structural Biology of HZI: "Even boiling is not able to break down its form." Usually, human proteins remain stable up to about 40C. Higher temperatures are of course not found in the body, but the stability of C4BP has a completely different purpose: "As is the case with all components of the complement system, the C4b binding protein is present in blood plasma. The proteins are exposed to enormous shear forces in the blood stream", explains Dr. Andrea Scrima, head of the junior research group "Structural Biology of Autophagy" at HZI. Therefore, the protein needs a high stability in order to be able to withstand these forces.

The researchers now would like to make use of the spatial structure. Their discoveries have facilitated biochemical synthesis of the molecule. In the context of replication within a test tube, the researchers can undertake alterations in a targeted way: "Instead of the seven alpha chains, we could implement other biomolecules", claims Prof. Harald Kolmar, director of the work group Applied Biochemistry at the Institute for Organic Chemistry and Biochemistry at the Technische Universitt Darmstadt. "We can use the oligomerisation domain as a framework, in order to decorate it with drug molecules." These could be vaccines, for example. Seven with one stroke, by means of the seven-fold binding capability. Bundled in this manner, more active ingredient could make its way to its target. The dosage could be reduced but the immune system would still be considerably stimulated. "It is thereby possible in the future that bottlenecks, limiting the supply of vaccine, could be avoided and side effects reduced", says Kolmar.

###

Original publication:

Thomas Hofmeyer*, Stefan Schmelz*, Matteo T. Degiacomi, Matteo Dal Peraro, Matin Daneschdar, Andrea Scrima, Joop van den Heuvel, Dirk W. Heinz, Harald Kolmar, * contributed equally

Arranged Sevenfold: Structural Insights into the C-Terminal Oligomerization Domain of Human C4b-Binding Protein Journal of Molecular Biology, 2013, DOI: 10.1016/j.jmb.2012.12.017

The Helmholtz Centre for Infection Research:

At the Helmholtz Centre for Infection Research (HZI) in Braunschweig, scientists are studying microbial virulence factors, host-pathogen interactions and immunity. The goal is to develop strategies for the diagnosis, prevention and therapy of human infectious diseases. http://www.helmholtz-hzi.de/en

The Technische Universitt Darmstadt:

The Technische Universitt (TU) Darmstadt is one of Germany's leading technical universities. Its around 300 professors, 4,500 scientific and administrative employees and 25,000 students devote their talents and best efforts to the significant future research fields energy, mobility, communications and information technologies, housing and living.

http://www.tu-darmstadt.de


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Protein shaped like a spider [ Back to EurekAlert! ] Public release date: 26-Apr-2013
[ | E-mail | Share Share ]

Contact: Dr. Jan Grabowski
jan.grabowski@helmholtz-hzi.de
49-531-618-11407
Helmholtz Centre for Infection Research

Joint press release of the Helmholtz Centre for Infection Research and the Technische Universitat Darmstadt -- The immune protein C4BP is potentially suitable as a transporter for drugs

This press release is available in German.

The protein C4BP is similar to a spider in its spatial form with eight "arms". The structure of the "spider body" has recently been described in detail by researchers from the Helmholtz Centre for Infection Research (HZI) in Braunschweig and the Technische Universitt Darmstadt. This leads the scientists to unconventional ideas the protein is possibly suitable as a scaffold for the transport of active pharmaceutical substances, particularly biomolecules. The researchers are publishing their results in the current edition of the international journal Journal of Molecular Biology.

The so-called complement system is a part of the innate immune defence within the human body: more than sixty different proteins form one of the first countermeasures against invading pathogens. One of them is the C4b binding protein known as C4BP. It is involved in the immune defence against bacteria in the blood. How precisely such protein substance carries out its function or how it interacts with other molecules this can only be predicted by scientists once they have identified the spatial structure of the molecule. Structural biologists therefore examine the substance in its purest form with x-ray machines and are able to reconstruct the spatial design in a computer. Regarding the case of the recently-described C4BP, they found out that it has eight "arms" and thus resembles a spider to a certain degree. Seven of the "arms" are identical as "alpha chains", while the eighth, a "beta chain" is different from the others. The spider body that holds these side chains together is called the oligomerisation domain. Its structure was of special interest to researchers, since it determines the spatial alignment of the "arms".

The newly-described structure allows two possible variants. "However, there is one of these two possibilities that is more feasible because it is much more stable", says Thomas Hofmeyer, PhD student at the Institute for Organic Chemistry and Biochemistry of TU Darmstadt and first author for the publication. And the C4BP is quite stable, as explained by the other first author Dr. Stefan Schmelz from the Department of Molecular Structural Biology of HZI: "Even boiling is not able to break down its form." Usually, human proteins remain stable up to about 40C. Higher temperatures are of course not found in the body, but the stability of C4BP has a completely different purpose: "As is the case with all components of the complement system, the C4b binding protein is present in blood plasma. The proteins are exposed to enormous shear forces in the blood stream", explains Dr. Andrea Scrima, head of the junior research group "Structural Biology of Autophagy" at HZI. Therefore, the protein needs a high stability in order to be able to withstand these forces.

The researchers now would like to make use of the spatial structure. Their discoveries have facilitated biochemical synthesis of the molecule. In the context of replication within a test tube, the researchers can undertake alterations in a targeted way: "Instead of the seven alpha chains, we could implement other biomolecules", claims Prof. Harald Kolmar, director of the work group Applied Biochemistry at the Institute for Organic Chemistry and Biochemistry at the Technische Universitt Darmstadt. "We can use the oligomerisation domain as a framework, in order to decorate it with drug molecules." These could be vaccines, for example. Seven with one stroke, by means of the seven-fold binding capability. Bundled in this manner, more active ingredient could make its way to its target. The dosage could be reduced but the immune system would still be considerably stimulated. "It is thereby possible in the future that bottlenecks, limiting the supply of vaccine, could be avoided and side effects reduced", says Kolmar.

###

Original publication:

Thomas Hofmeyer*, Stefan Schmelz*, Matteo T. Degiacomi, Matteo Dal Peraro, Matin Daneschdar, Andrea Scrima, Joop van den Heuvel, Dirk W. Heinz, Harald Kolmar, * contributed equally

Arranged Sevenfold: Structural Insights into the C-Terminal Oligomerization Domain of Human C4b-Binding Protein Journal of Molecular Biology, 2013, DOI: 10.1016/j.jmb.2012.12.017

The Helmholtz Centre for Infection Research:

At the Helmholtz Centre for Infection Research (HZI) in Braunschweig, scientists are studying microbial virulence factors, host-pathogen interactions and immunity. The goal is to develop strategies for the diagnosis, prevention and therapy of human infectious diseases. http://www.helmholtz-hzi.de/en

The Technische Universitt Darmstadt:

The Technische Universitt (TU) Darmstadt is one of Germany's leading technical universities. Its around 300 professors, 4,500 scientific and administrative employees and 25,000 students devote their talents and best efforts to the significant future research fields energy, mobility, communications and information technologies, housing and living.

http://www.tu-darmstadt.de


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-04/hcfi-psl042613.php

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শুক্রবার, ২৬ এপ্রিল, ২০১৩

How late should you play when you're pregnant? - ArtsJournal

The question has arisen in German orchestras as a result of a law designed to protect expectant mothers and unborn babies. Germany has the lowest birth rate in the Europe and the fastest shrinking demographics, so you can see why politicians are concerned.

The Mutterschutzgesetz (MuSChG) decrees that a woman cannot be required to work during her last six weeks of pregnancy. If she insists on coming to work, the employer has to put in place a whole range of protective measures to shield her from, for example, high noise levels. This is causing much furrowing of brows in orchestras. An article in the May edition of Das Orchester (not online) shows how they are trying to cope.

This is, without doubt, an enlightened piece of legislation, but I?m not sure how sensible it is for musicians. There are plenty of cases where a singer has given birth between two acts of an opera without harmful effects (except for the audience, which had to wait around and accept a second-act substitute). I often see musicians in advanced stages of pregnancy playing dreamily on stage to the benefit of all around them. Civilisation has advanced several light-years beyond the time when expectant mothers were put in purdah for the duration.

Shouldn?t musicians be exempted from this mollycoddling law? In the absence of a specific medical concern in an individual case, is there any reason a musician should not be allowed to play ? if she wants to ? up to the last minute??naked-and-pregnant

Source: http://www.artsjournal.com/slippeddisc/2013/04/how-late-should-you-play-when-youre-pregnant.html

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Jim Hoft's Breaking Bombshell of the Day: Victim of Terrorism Visited by Michelle Obama! (Little green footballs)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/301342899?client_source=feed&format=rss

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Significant step forward in combating antibiotic resistance

Apr. 24, 2013 ? Antibiotic resistance is a global problem. The World Health Organisation (WHO) estimates that for tuberculosis alone multi-drug resistance accounts for more than 150,000 deaths each year. WHO warns of "a doomsday scenario of a world without antibiotics," in which antibiotic resistance will turn common infections into incurable killers and make routine surgeries a high-risk gamble.

Certain types of bacteria are a scourge of the hospital environment because they are extremely resistant to antibiotics and consequently difficult, if not impossible, to treat. This group of bacteria is classified as 'gram-negative' because their cells have a double membrane or outer layer, compared with gram-positive bacteria, which just have one outer layer.

Not only are these cells difficult to penetrate in the first instance, due to their double membrane, but they have effective 'pumps' which quickly reject anything that interferes with the activity of protein-building within the cell and the development of the protective cell wall.

This research, which was funded by the Wellcome Trust, gives for the first time a clear insight into how these protein components of the pump work together to transport an antibiotic from the cell.

Examples of gram-negative bacteria include those which cause food poisoning, meningitis, gonorrhoea and respiratory problems. Since the antibiotic is an interfering agent, many of these pathogenic bacteria use the membrane pumps to transport the medication out of the cell.

The pumps are made up of three different proteins within the cell that work together to bring about the movement. Research lead, Professor Adrian Walmsley from Durham University's School of Biological and Biomedical Sciences explained:

"Patients with bacterial infections are often treated with antibiotics, but since many strains are resistant to one or more of these drugs, clinicians often try to bring such infections under control by prescribing a combination of different types of antibiotics in the hope that they will override the resistance mechanisms. This sometimes works, but other times it does not. Pumps exacerbate this situation by reducing the effective concentration of the drug inside the cell. "

"By investigating how these pumps function, we have been able to identify the molecular events that are involved in binding and transporting an antibiotic from the cell. This advance in our understanding will ultimately aid the development of 'pump blockers'. This is important because these pumps often confer resistance to multiple, structurally unrelated, drugs; which means that they could also be resistant to new drugs which have never been used before."

Dr Vassiliy Bavro from the the Institute of Microbiology and Infection at the University of Birmingham said: "This study greatly expands our understanding of the mechanistic aspects of the pump function, and in particular challenges our previous concepts of energy requirements for pump assembly and cycling. By elucidating the intricate details of how these essential nanomachines come together, it also provides a new working model of their functional cycle in general, paving the way to development of novel approaches to disrupting their function."

Dr Ted Bianco, Acting Director of the Wellcome Trust, said: "A world without antibiotics is a world where simple surgery becomes a life-threatening procedure, where a scratch from a rose might prove fatal, and where diseases like tuberculosis return with a ferocity not seen in Britain since the Victorian era. This is why fundamental research to understand the mechanisms of antibiotic resistance is so important. Only when we know what we're up against can researchers begin to design new antibacterial agents to help us win the war against bacterial infections."

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Story Source:

The above story is reprinted from materials provided by Durham University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Thamarai K. Janganan, Vassiliy N. Bavro, Li Zhang, Maria In?s Borges-Walmsley, Adrian R. Walmsley. Tripartite efflux pumps: energy is required for dissociation, but not assembly or opening of the outer membrane channel of the pump. Molecular Microbiology, 2013; 88 (3): 590 DOI: 10.1111/mmi.12211

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/9lrScfLULdA/130424222554.htm

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